Two sample MR report
Total lipids in medium VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | 0.0988181 | 0.1718270 | 0.5793133 |
| Weighted median | 11 | 0.2414479 | 0.0850822 | 0.0045423 |
| Inverse variance weighted | 11 | 0.1886792 | 0.0711211 | 0.0079797 |
| Simple mode | 11 | 0.2028048 | 0.1568656 | 0.2251312 |
| Weighted mode | 11 | 0.2626907 | 0.1009539 | 0.0263969 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.29493 | 9 | 0.1971888 |
| Inverse variance weighted | 12.75254 | 10 | 0.2378384 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0119871 | 0.0207111 | 0.5769366 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002796 | 0 | TRUE | 0.0346595 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
