Two sample MR report
Concentration of medium VLDL particles against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.0249669 | 0.1695866 | 0.8856203 |
| Weighted median | 13 | 0.2846880 | 0.0840642 | 0.0007078 |
| Inverse variance weighted | 13 | 0.2102886 | 0.0726476 | 0.0037959 |
| Simple mode | 13 | 0.1297035 | 0.1576110 | 0.4265966 |
| Weighted mode | 13 | 0.2598757 | 0.1102493 | 0.0362376 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.07626 | 11 | 0.1790323 |
| Inverse variance weighted | 17.06464 | 12 | 0.1471818 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0232929 | 0.0193386 | 0.2536803 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002784 | 0 | TRUE | 0.035256 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
