Two sample MR report
Phospholipids in medium VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.2167441 | 0.1634305 | 0.2094571 |
| Weighted median | 14 | 0.2356755 | 0.0811862 | 0.0036972 |
| Inverse variance weighted | 14 | 0.1752123 | 0.0653962 | 0.0073789 |
| Simple mode | 14 | 0.2688111 | 0.1666798 | 0.1308018 |
| Weighted mode | 14 | 0.2860326 | 0.1042502 | 0.0167377 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.10875 | 12 | 0.1863056 |
| Inverse variance weighted | 16.21350 | 13 | 0.2377931 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0049754 | 0.0178118 | 0.7847454 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002743 | 0 | TRUE | 0.0304225 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
