Two sample MR report
Triglycerides in medium VLDL against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.2003936 | 0.1689806 | 0.2630759 |
| Weighted median | 12 | 0.2326605 | 0.0894590 | 0.0093020 |
| Inverse variance weighted | 12 | 0.1706439 | 0.0648845 | 0.0085394 |
| Simple mode | 12 | 0.2469137 | 0.1571562 | 0.1444516 |
| Weighted mode | 12 | 0.2766602 | 0.1128095 | 0.0321057 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.49706 | 10 | 0.3201244 |
| Inverse variance weighted | 11.53957 | 11 | 0.3992274 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0038231 | 0.0198838 | 0.8513778 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002287 | 0 | TRUE | 0.0491481 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
