Two sample MR report
Valine against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.2470502 | 0.5902210 | 0.7036885 |
| Weighted median | 5 | -0.2408464 | 0.1349912 | 0.0743970 |
| Inverse variance weighted | 5 | -0.2268320 | 0.1079436 | 0.0356064 |
| Simple mode | 5 | -0.3015236 | 0.2053699 | 0.2159665 |
| Weighted mode | 5 | -0.0736261 | 0.1695177 | 0.6864534 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.405591 | 3 | 0.4925948 |
| Inverse variance weighted | 3.072530 | 4 | 0.5457620 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0442239 | 0.054152 | 0.4739394 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.62e-05 | 0 | TRUE | 0.2964533 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
