Two sample MR report
1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.1419364 | 0.1445206 | 0.3711442 |
| Weighted median | 7 | 0.0959138 | 0.0676029 | 0.1559627 |
| Inverse variance weighted | 7 | 0.1247167 | 0.0558692 | 0.0255953 |
| Simple mode | 7 | 0.2416090 | 0.1378909 | 0.1302979 |
| Weighted mode | 7 | 0.0539339 | 0.0700379 | 0.4704823 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.539725 | 5 | 0.2571822 |
| Inverse variance weighted | 6.562334 | 6 | 0.3632227 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0032495 | 0.0247152 | 0.900525 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001429 | 0 | TRUE | 0.0010657 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
