Two sample MR report
21-hydroxypregnenolone disulfate levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0113062 | 0.1747192 | 0.9505067 |
| Weighted median | 8 | 0.0864278 | 0.0652389 | 0.1852409 |
| Inverse variance weighted | 8 | 0.1045016 | 0.0527120 | 0.0474231 |
| Simple mode | 8 | 0.0630610 | 0.0946913 | 0.5267638 |
| Weighted mode | 8 | 0.0896280 | 0.0793225 | 0.2957363 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.828447 | 6 | 0.9347808 |
| Inverse variance weighted | 2.141453 | 7 | 0.9515979 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0166202 | 0.029707 | 0.5960916 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006663 | 0 | TRUE | 0.0254001 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
