Two sample MR report
5alpha-androstan-3alpha,17alpha-diol monosulfate levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0507334 | 0.0631387 | 0.4667069 |
| Weighted median | 6 | -0.0799907 | 0.0420532 | 0.0571542 |
| Inverse variance weighted | 6 | -0.0747213 | 0.0336540 | 0.0263997 |
| Simple mode | 6 | -0.0840476 | 0.0593544 | 0.2159353 |
| Weighted mode | 6 | -0.0850171 | 0.0438625 | 0.1103159 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.095979 | 4 | 0.7181112 |
| Inverse variance weighted | 2.297605 | 5 | 0.8066185 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0085948 | 0.0191409 | 0.6766644 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0024469 | 0 | TRUE | 0.0003465 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
