Two sample MR report
Androstenediol (3beta,17beta) monosulfate (2) levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.2207375 | 0.1711972 | 0.3262616 |
| Weighted median | 4 | -0.2007702 | 0.0916681 | 0.0285106 |
| Inverse variance weighted | 4 | -0.1560715 | 0.0753592 | 0.0383556 |
| Simple mode | 4 | -0.2408269 | 0.1348222 | 0.1720340 |
| Weighted mode | 4 | -0.2029586 | 0.1023211 | 0.1415686 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.746762 | 2 | 0.2532493 |
| Inverse variance weighted | 3.013341 | 3 | 0.3895729 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0115079 | 0.0261203 | 0.7025674 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001407 | 0 | TRUE | 0.3146578 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
