Two sample MR report
Acisoga levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.1197167 | 0.1665409 | 0.5119918 |
| Weighted median | 6 | -0.1153468 | 0.0725229 | 0.1117248 |
| Inverse variance weighted | 6 | -0.1456861 | 0.0584936 | 0.0127515 |
| Simple mode | 6 | -0.1062568 | 0.1077473 | 0.3693375 |
| Weighted mode | 6 | -0.0963797 | 0.0952407 | 0.3579946 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.776185 | 4 | 0.2164980 |
| Inverse variance weighted | 5.817645 | 5 | 0.3243692 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.005501 | 0.0324653 | 0.8736721 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007904 | 0 | TRUE | 0.0192594 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
