Two sample MR report
Beta-hydroxyisovalerate levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.3621300 | 0.1811637 | 0.1394732 |
| Weighted median | 5 | -0.1976936 | 0.0862826 | 0.0219499 |
| Inverse variance weighted | 5 | -0.1517443 | 0.0685220 | 0.0267921 |
| Simple mode | 5 | -0.2100509 | 0.1024645 | 0.1096920 |
| Weighted mode | 5 | -0.2084356 | 0.0963964 | 0.0966424 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.685857 | 3 | 0.4426361 |
| Inverse variance weighted | 4.244624 | 4 | 0.3739108 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0393574 | 0.0315236 | 0.3004048 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002681 | 0 | TRUE | 0.1553167 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
