Two sample MR report
Dihydroorotate levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0784327 | 0.1299581 | 0.5724917 |
| Weighted median | 7 | 0.1002968 | 0.0590395 | 0.0893553 |
| Inverse variance weighted | 7 | 0.1225141 | 0.0495524 | 0.0134204 |
| Simple mode | 7 | 0.1816746 | 0.0919798 | 0.0956639 |
| Weighted mode | 7 | 0.0960492 | 0.0639512 | 0.1838006 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.228932 | 5 | 0.8166461 |
| Inverse variance weighted | 2.363559 | 6 | 0.8834141 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0089485 | 0.0243884 | 0.7286982 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0019081 | 0 | TRUE | 0.0001448 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
