Two sample MR report
X-21286 levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.2375343 | 0.6532573 | 0.7509845 |
| Weighted median | 4 | -0.2179515 | 0.1177822 | 0.0642468 |
| Inverse variance weighted | 4 | -0.2467928 | 0.0937822 | 0.0084996 |
| Simple mode | 4 | -0.1241101 | 0.1690913 | 0.5161207 |
| Weighted mode | 4 | -0.2062916 | 0.1353296 | 0.2248163 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.073769 | 2 | 0.2150501 |
| Inverse variance weighted | 3.074087 | 3 | 0.3803428 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0010097 | 0.0701321 | 0.9898202 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001491 | 0 | TRUE | 0.2898484 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
