Two sample MR report
Orotidine levels against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0970372 | 0.0486205 | 0.2957016 |
| Weighted median | 3 | -0.0881801 | 0.0386340 | 0.0224628 |
| Inverse variance weighted | 3 | -0.0818487 | 0.0382824 | 0.0325146 |
| Simple mode | 3 | -0.1166440 | 0.0811609 | 0.2872173 |
| Weighted mode | 3 | -0.0915780 | 0.0393557 | 0.1454460 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.251470 | 1 | 0.2632719 |
| Inverse variance weighted | 1.796324 | 2 | 0.4073177 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0131882 | 0.0199873 | 0.6286902 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0296014 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
