Two sample MR report
Uridine to pseudouridine ratio against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -1.7791561 | 1.6203224 | 0.4702769 |
| Weighted median | 3 | 0.1554900 | 0.1505277 | 0.3016197 |
| Inverse variance weighted | 3 | 0.2972368 | 0.1320583 | 0.0243982 |
| Simple mode | 3 | 0.1534995 | 0.2059886 | 0.5338317 |
| Weighted mode | 3 | 0.1534995 | 0.2012416 | 0.5252912 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9629472 | 1 | 0.3264454 |
| Inverse variance weighted | 2.6135001 | 2 | 0.2706984 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2237077 | 0.1741271 | 0.4210674 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001116 | 0 | TRUE | 0.360188 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
