Two sample MR report
Tyrosine to pyruvate ratio against Malignant_melanoma_of_skin
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.2527765 | 0.2394591 | 0.4827805 |
| Weighted median | 3 | -0.2848728 | 0.1362767 | 0.0365819 |
| Inverse variance weighted | 3 | -0.3306112 | 0.1144867 | 0.0038798 |
| Simple mode | 3 | -0.2614411 | 0.1599157 | 0.2436995 |
| Weighted mode | 3 | -0.2630191 | 0.1766752 | 0.2749845 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5348622 | 1 | 0.4645698 |
| Inverse variance weighted | 0.6718231 | 2 | 0.7146863 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0105246 | 0.0284384 | 0.7743487 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.41e-05 | 0 | TRUE | 0.5251524 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
