

# Two sample MR report

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## Omega-3 fatty acids || id:met-d-Omega_3 against Cardiovascular disease || id:ebi-a-GCST90086053

Date: **20 December, 2025**

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### Results from two sample MR:


|method                    | nsnp|     b|    se|  pval|
|:-------------------------|----:|-----:|-----:|-----:|
|MR Egger                  |   74| 0.108| 0.078| 0.172|
|Weighted median           |   74| 0.109| 0.070| 0.119|
|Inverse variance weighted |   74| 0.106| 0.057| 0.064|
|Simple mode               |   74| 0.310| 0.163| 0.061|
|Weighted mode             |   74| 0.145| 0.057| 0.013|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 96.7|   72|  0.028|
|Inverse variance weighted | 96.7|   73|  0.033|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|               0| 0.005| 0.961|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           0.003|              0|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Omega3_fatty_acids__idmetdOmega3_against_Cardiovascular_disease__idebiaGCST90086053chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Omega3_fatty_acids__idmetdOmega3_against_Cardiovascular_disease__idebiaGCST90086053chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Omega3_fatty_acids__idmetdOmega3_against_Cardiovascular_disease__idebiaGCST90086053chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Omega3_fatty_acids__idmetdOmega3_against_Cardiovascular_disease__idebiaGCST90086053chunk8-1.png)
