

# Two sample MR report

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## EBI-a-GCST006909 against PRKAB1-UKBPPP

Date: **08 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |   34|  0.007| 0.023| 0.752|
|Weighted median           |   34|  0.002| 0.015| 0.907|
|Inverse variance weighted |   34|  0.002| 0.011| 0.883|
|Simple mode               |   34| -0.008| 0.030| 0.801|
|Weighted mode             |   34| -0.002| 0.028| 0.938|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 35.2|   32|  0.319|
|Inverse variance weighted | 35.3|   33|  0.360|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.001| 0.005| 0.778|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.866|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/EBIaGCST006909_against_PRKAB1UKBPPPchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/EBIaGCST006909_against_PRKAB1UKBPPPchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/EBIaGCST006909_against_PRKAB1UKBPPPchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/EBIaGCST006909_against_PRKAB1UKBPPPchunk8-1.png)
