Two sample MR report
EBI-a-GCST006909 against INSR-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 34 | 0.006 | 0.026 | 0.812 |
| Weighted median | 34 | -0.002 | 0.016 | 0.901 |
| Inverse variance weighted | 34 | -0.004 | 0.012 | 0.771 |
| Simple mode | 34 | -0.046 | 0.039 | 0.245 |
| Weighted mode | 34 | -0.043 | 0.035 | 0.234 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 43.3 | 32 | 0.088 |
| Inverse variance weighted | 43.5 | 33 | 0.104 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.005 | 0.664 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.926 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
