Two sample MR report
EBI-a-GCST006909 against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 34 | -0.013 | 0.021 | 0.523 |
| Weighted median | 34 | -0.001 | 0.014 | 0.940 |
| Inverse variance weighted | 34 | 0.000 | 0.010 | 0.969 |
| Simple mode | 34 | -0.011 | 0.031 | 0.729 |
| Weighted mode | 34 | -0.010 | 0.030 | 0.744 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 28.1 | 32 | 0.662 |
| Inverse variance weighted | 28.7 | 33 | 0.683 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.003 | 0.004 | 0.477 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.855 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
