Two sample MR report
EBI-a-GCST006909 against PRKAB1-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 34 | 0.007 | 0.023 | 0.752 |
| Weighted median | 34 | 0.002 | 0.015 | 0.907 |
| Inverse variance weighted | 34 | 0.002 | 0.011 | 0.883 |
| Simple mode | 34 | -0.008 | 0.030 | 0.801 |
| Weighted mode | 34 | -0.002 | 0.028 | 0.938 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 35.2 | 32 | 0.319 |
| Inverse variance weighted | 35.3 | 33 | 0.360 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001 | 0.005 | 0.778 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.866 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
