Two sample MR report
FA against INSR-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.027 | 0.048 | 0.603 |
| Weighted median | 7 | -0.008 | 0.014 | 0.541 |
| Inverse variance weighted | 7 | -0.004 | 0.012 | 0.775 |
| Simple mode | 7 | -0.002 | 0.024 | 0.938 |
| Weighted mode | 7 | -0.009 | 0.018 | 0.624 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.23 | 5 | 0.144 |
| Inverse variance weighted | 8.64 | 6 | 0.195 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.008 | 0.016 | 0.638 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.406 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
