Two sample MR report
FA against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.004 | 0.037 | 0.910 |
| Weighted median | 7 | 0.002 | 0.012 | 0.857 |
| Inverse variance weighted | 7 | -0.002 | 0.010 | 0.862 |
| Simple mode | 7 | 0.002 | 0.017 | 0.911 |
| Weighted mode | 7 | 0.002 | 0.015 | 0.892 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.48 | 5 | 0.360 |
| Inverse variance weighted | 5.52 | 6 | 0.479 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.002 | 0.012 | 0.871 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.402 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
