Two sample MR report
MD against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.001 | 0.027 | 0.969 |
| Weighted median | 5 | -0.002 | 0.011 | 0.871 |
| Inverse variance weighted | 5 | -0.002 | 0.010 | 0.809 |
| Simple mode | 5 | 0.000 | 0.017 | 0.989 |
| Weighted mode | 5 | -0.001 | 0.013 | 0.930 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.07 | 3 | 0.785 |
| Inverse variance weighted | 1.07 | 4 | 0.899 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.001 | 0.011 | 0.964 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.306 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
