Two sample MR report
Small vessel stroke against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 32 | -0.056 | 0.039 | 0.161 |
| Weighted median | 32 | -0.005 | 0.017 | 0.760 |
| Inverse variance weighted | 32 | -0.008 | 0.014 | 0.538 |
| Simple mode | 32 | -0.025 | 0.037 | 0.509 |
| Weighted mode | 32 | -0.026 | 0.035 | 0.463 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 34.6 | 30 | 0.257 |
| Inverse variance weighted | 36.6 | 31 | 0.226 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.008 | 0.006 | 0.202 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.017 | 0 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
