Two sample MR report
WMH against INSR-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.030 | 0.177 | 0.871 |
| Weighted median | 7 | 0.044 | 0.057 | 0.445 |
| Inverse variance weighted | 7 | 0.032 | 0.045 | 0.473 |
| Simple mode | 7 | 0.066 | 0.094 | 0.506 |
| Weighted mode | 7 | 0.027 | 0.083 | 0.759 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.79 | 5 | 0.327 |
| Inverse variance weighted | 5.79 | 6 | 0.447 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0 | 0.013 | 0.992 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.429 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
