Two sample MR report
WMH against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.540 | 0.190 | 0.036 |
| Weighted median | 7 | -0.038 | 0.063 | 0.543 |
| Inverse variance weighted | 7 | -0.042 | 0.074 | 0.572 |
| Simple mode | 7 | -0.014 | 0.128 | 0.913 |
| Weighted mode | 7 | -0.124 | 0.098 | 0.253 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.76 | 5 | 0.170 |
| Inverse variance weighted | 19.25 | 6 | 0.004 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.039 | 0.014 | 0.042 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.441 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
