Two sample MR report
WMH against PRKAB1-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.090 | 0.255 | 0.740 |
| Weighted median | 7 | -0.008 | 0.056 | 0.883 |
| Inverse variance weighted | 7 | 0.030 | 0.065 | 0.638 |
| Simple mode | 7 | -0.012 | 0.088 | 0.898 |
| Weighted mode | 7 | -0.013 | 0.074 | 0.864 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.6 | 5 | 0.027 |
| Inverse variance weighted | 13.2 | 6 | 0.040 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.009 | 0.019 | 0.646 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.441 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
