Two sample MR report
cerebral microbleeds against GLP1R-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.047 | 0.059 | 0.462 |
| Weighted median | 7 | 0.011 | 0.025 | 0.672 |
| Inverse variance weighted | 7 | -0.002 | 0.019 | 0.929 |
| Simple mode | 7 | 0.024 | 0.038 | 0.560 |
| Weighted mode | 7 | 0.021 | 0.035 | 0.573 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.71 | 5 | 0.593 |
| Inverse variance weighted | 4.36 | 6 | 0.628 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.012 | 0.015 | 0.454 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.749 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
