Two sample MR report
cerebral microbleeds against INSR-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.024 | 0.080 | 0.780 |
| Weighted median | 7 | 0.058 | 0.026 | 0.024 |
| Inverse variance weighted | 7 | 0.041 | 0.024 | 0.086 |
| Simple mode | 7 | 0.071 | 0.040 | 0.124 |
| Weighted mode | 7 | 0.069 | 0.034 | 0.085 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.34 | 5 | 0.096 |
| Inverse variance weighted | 9.43 | 6 | 0.151 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.005 | 0.021 | 0.828 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.759 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
