Two sample MR report
cerebral microbleeds against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.070 | 0.064 | 0.326 |
| Weighted median | 7 | 0.024 | 0.026 | 0.362 |
| Inverse variance weighted | 7 | 0.010 | 0.021 | 0.625 |
| Simple mode | 7 | 0.051 | 0.046 | 0.309 |
| Weighted mode | 7 | 0.050 | 0.046 | 0.317 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.97 | 5 | 0.223 |
| Inverse variance weighted | 8.32 | 6 | 0.216 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.017 | 0.017 | 0.371 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.751 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
