Two sample MR report
cerebral microbleeds against PRKAB1-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.035 | 0.057 | 0.568 |
| Weighted median | 7 | -0.016 | 0.025 | 0.535 |
| Inverse variance weighted | 7 | -0.021 | 0.019 | 0.251 |
| Simple mode | 7 | -0.003 | 0.036 | 0.938 |
| Weighted mode | 7 | -0.014 | 0.033 | 0.693 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.55 | 5 | 0.474 |
| Inverse variance weighted | 5.62 | 6 | 0.467 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.016 | 0.015 | 0.347 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.756 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
