Two sample MR report
enlarged perivascular spaces against INSR-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.195 | 0.917 | 0.866 |
| Weighted median | 3 | -0.033 | 0.219 | 0.881 |
| Inverse variance weighted | 3 | -0.082 | 0.195 | 0.674 |
| Simple mode | 3 | 0.094 | 0.285 | 0.772 |
| Weighted mode | 3 | 0.106 | 0.315 | 0.769 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.21 | 1 | 0.272 |
| Inverse variance weighted | 1.32 | 2 | 0.516 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.007 | 0.024 | 0.808 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.814 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
