Two sample MR report
enlarged perivascular spaces against PCSK9-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -2.063 | 1.507 | 0.402 |
| Weighted median | 3 | -0.692 | 0.239 | 0.004 |
| Inverse variance weighted | 3 | -0.474 | 0.370 | 0.200 |
| Simple mode | 3 | -0.743 | 0.296 | 0.129 |
| Weighted mode | 3 | -0.758 | 0.264 | 0.103 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.71 | 1 | 0.054 |
| Inverse variance weighted | 8.08 | 2 | 0.018 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.043 | 0.04 | 0.474 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.84 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
