Two sample MR report
enlarged perivascular spaces against PRKAB1-UKBPPP
Date: 08 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.315 | 0.815 | 0.765 |
| Weighted median | 3 | -0.116 | 0.210 | 0.583 |
| Inverse variance weighted | 3 | -0.078 | 0.190 | 0.682 |
| Simple mode | 3 | -0.116 | 0.259 | 0.698 |
| Weighted mode | 3 | -0.116 | 0.270 | 0.708 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.041 | 1 | 0.839 |
| Inverse variance weighted | 0.131 | 2 | 0.937 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.006 | 0.021 | 0.815 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.811 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
