

# Two sample MR report

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## RBC distribution width (RDW) against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4| -0.2712454| 0.3105696| 0.4745526|
|Weighted median           |    4| -0.2459515| 0.1026414| 0.0165650|
|Inverse variance weighted |    4| -0.2144419| 0.1038034| 0.0388429|
|Simple mode               |    4| -0.3801305| 0.1611891| 0.0995542|
|Weighted mode             |    4| -0.2346017| 0.1171841| 0.1390573|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 4.047139|    2| 0.1321828|
|Inverse variance weighted | 4.128140|    3| 0.2479556|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|        0.001424| 0.0071173| 0.8599226|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|           2e-07|              0|TRUE                     |    0.9534698|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/RBC_distribution_width_RDW_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/RBC_distribution_width_RDW_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/RBC_distribution_width_RDW_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/RBC_distribution_width_RDW_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
