

# Two sample MR report

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## IL_16 against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    4| 0.0103262| 0.0125568| 0.4973167|
|Weighted median           |    4| 0.0133431| 0.0080513| 0.0974682|
|Inverse variance weighted |    4| 0.0150496| 0.0073943| 0.0418215|
|Simple mode               |    4| 0.0145156| 0.0141326| 0.3799449|
|Weighted mode             |    4| 0.0120547| 0.0086688| 0.2585515|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.373056|    2| 0.3052794|
|Inverse variance weighted | 2.658323|    3| 0.4473565|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0016847| 0.0034359| 0.6724166|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0016331|              0|TRUE                     |    0.0224742|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/IL16_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/IL16_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/IL16_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/IL16_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
