

# Two sample MR report

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## Interleukin-10 receptor subunit alpha levels against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0352468| 0.0677554| 0.6303847|
|Weighted median           |    6| 0.0615171| 0.0272820| 0.0241419|
|Inverse variance weighted |    6| 0.0597910| 0.0218217| 0.0061444|
|Simple mode               |    6| 0.0705213| 0.0440500| 0.1702892|
|Weighted mode             |    6| 0.0736503| 0.0424173| 0.1430200|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.954722|    4| 0.5654310|
|Inverse variance weighted | 3.101131|    5| 0.6843978|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0021854| 0.0057114| 0.7214535|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|         2.7e-05|              0|TRUE                     |     0.639228|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin10_receptor_subunit_alpha_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin10_receptor_subunit_alpha_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin10_receptor_subunit_alpha_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin10_receptor_subunit_alpha_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
