

# Two sample MR report

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## Amyotrophic lateral sclerosis || id:ieu-a-1085 against FGF_BASIC

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.7403558| 0.3878249| 0.0665605|
|Weighted median           |   30| -0.3775911| 0.2340401| 0.1066662|
|Inverse variance weighted |   30| -0.3827948| 0.1633227| 0.0190887|
|Simple mode               |   30| -0.8451983| 0.4147742| 0.0507915|
|Weighted mode             |   30| -0.5070952| 0.3538028| 0.1624744|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 29.20744|   28| 0.4020631|
|Inverse variance weighted | 30.28500|   29| 0.3998786|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0096263| 0.0094712| 0.3181547|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0238754|      0.0047341|TRUE                     |            0|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_FGFBASICchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_FGFBASICchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_FGFBASICchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_FGFBASICchunk8-1.png)
