

# Two sample MR report

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## Amyotrophic lateral sclerosis || id:ieu-a-1085 against SCGF_B

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   30| -0.9702553| 0.5524041| 0.0899497|
|Weighted median           |   30| -0.5911613| 0.3228989| 0.0671313|
|Inverse variance weighted |   30| -0.5206371| 0.2295975| 0.0233531|
|Simple mode               |   30| -0.6345948| 0.5950513| 0.2950169|
|Weighted mode             |   30| -0.6860091| 0.4646188| 0.1505874|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 26.22406|   28| 0.5607297|
|Inverse variance weighted | 27.02489|   29| 0.5703622|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0119781| 0.0133851| 0.3784754|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0238754|      0.0086519|TRUE                     |    0.0002865|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_SCGFBchunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_SCGFBchunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_SCGFBchunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Amyotrophic_lateral_sclerosis__idieua1085_against_SCGFBchunk8-1.png)
