

# Two sample MR report

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## Fms-related tyrosine kinase 3 ligand levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   22| -0.1763363| 0.1034574| 0.1037873|
|Weighted median           |   22| -0.0701412| 0.0529152| 0.1849922|
|Inverse variance weighted |   22| -0.0786842| 0.0374143| 0.0354613|
|Simple mode               |   22| -0.0280778| 0.0894268| 0.7566373|
|Weighted mode             |   22| -0.0449914| 0.0753018| 0.5565751|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 17.97907|   20| 0.5887874|
|Inverse variance weighted | 19.00404|   21| 0.5848811|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|         0.00882| 0.0087119| 0.3234348|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001104|              0|TRUE                     |    0.2331873|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Fmsrelated_tyrosine_kinase_3_ligand_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Fmsrelated_tyrosine_kinase_3_ligand_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Fmsrelated_tyrosine_kinase_3_ligand_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Fmsrelated_tyrosine_kinase_3_ligand_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk8-1.png)
