

# Two sample MR report

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## X-11315 against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    3| -0.0151114| 0.3008555| 0.9680507|
|Weighted median           |    3| -0.2268581| 0.1094698| 0.0382342|
|Inverse variance weighted |    3| -0.2239540| 0.0955652| 0.0191055|
|Simple mode               |    3| -0.2775276| 0.1401636| 0.1862489|
|Weighted mode             |    3| -0.1807755| 0.1265815| 0.2894384|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.0018165|    1| 0.9660043|
|Inverse variance weighted | 0.5377530|    2| 0.7642376|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0077815| 0.0106294| 0.5977001|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001178|              0|TRUE                     |    0.4176176|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/X11315_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/X11315_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/X11315_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/X11315_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
