

# Two sample MR report

---

## Hippurate levels against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    8| -0.1128132| 0.0543878| 0.0833971|
|Weighted median           |    8| -0.0566398| 0.0224730| 0.0117240|
|Inverse variance weighted |    8| -0.0543205| 0.0168843| 0.0012944|
|Simple mode               |    8| -0.0827337| 0.0367038| 0.0588420|
|Weighted mode             |    8| -0.0827337| 0.0350526| 0.0503212|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 5.528949|    6| 0.4779648|
|Inverse variance weighted | 6.808956|    7| 0.4490388|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|        0.006229| 0.0055057| 0.301081|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        6.03e-05|              0|TRUE                     |    0.5363859|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Hippurate_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Hippurate_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Hippurate_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Hippurate_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
