

# Two sample MR report

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## Interleukin-2 receptor subunit beta || id:prot-a-1519 against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|      b|    se|  pval|
|:-------------------------|----:|------:|-----:|-----:|
|MR Egger                  |    3|  0.579| 0.956| 0.653|
|Weighted median           |    3| -0.136| 0.068| 0.044|
|Inverse variance weighted |    3| -0.123| 0.058| 0.033|
|Simple mode               |    3| -0.191| 0.095| 0.183|
|Weighted mode             |    3| -0.192| 0.101| 0.197|

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### Heterogeneity tests


|method                    |    Q| Q_df| Q_pval|
|:-------------------------|----:|----:|------:|
|MR Egger                  | 1.44|    1|  0.229|
|Inverse variance weighted | 2.23|    2|  0.329|

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### Test for directional horizontal pleiotropy


| egger_intercept|    se|  pval|
|---------------:|-----:|-----:|
|          -0.097| 0.132| 0.596|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|               0|              0|TRUE                     |        0.369|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin2_receptor_subunit_beta__idprota1519_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin2_receptor_subunit_beta__idprota1519_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin2_receptor_subunit_beta__idprota1519_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin2_receptor_subunit_beta__idprota1519_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk8-1.png)
