

# Two sample MR report

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## beta-nerve growth factor levels against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.0301664| 0.0500884| 0.5566288|
|Weighted median           |   16|  0.0151977| 0.0225353| 0.5000610|
|Inverse variance weighted |   16|  0.0317428| 0.0159325| 0.0463347|
|Simple mode               |   16|  0.0909488| 0.0493649| 0.0852744|
|Weighted mode             |   16|  0.0916721| 0.0539829| 0.1101175|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 14.82570|   14| 0.3901723|
|Inverse variance weighted | 16.61672|   15| 0.3422879|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0052562| 0.0040417| 0.2144346|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        5.27e-05|              0|TRUE                     |    0.4801253|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/betanerve_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/betanerve_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/betanerve_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/betanerve_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
