

# Two sample MR report

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## Gamma-glutamyltyrosine against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    5| 0.1498077| 1.1996685| 0.9085209|
|Weighted median           |    5| 0.3625812| 0.1923230| 0.0593931|
|Inverse variance weighted |    5| 0.3630263| 0.1576813| 0.0213195|
|Simple mode               |    5| 0.4010226| 0.2446665| 0.1765441|
|Weighted mode             |    5| 0.3890118| 0.2330873| 0.1704506|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.4429131|    3| 0.9312417|
|Inverse variance weighted | 0.4750568|    4| 0.9758833|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0022925| 0.0127867| 0.8691379|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|       0.0001032|              0|TRUE                     |    0.4394753|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Gammaglutamyltyrosine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Gammaglutamyltyrosine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Gammaglutamyltyrosine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Gammaglutamyltyrosine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
