

# Two sample MR report

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## EDTA levels against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |    6| 0.0297486| 0.0597707| 0.6448059|
|Weighted median           |    6| 0.0514530| 0.0252902| 0.0419007|
|Inverse variance weighted |    6| 0.0469049| 0.0201609| 0.0199908|
|Simple mode               |    6| 0.0640466| 0.0382889| 0.1552419|
|Weighted mode             |    6| 0.0640466| 0.0374737| 0.1481271|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 2.027558|    4| 0.7306901|
|Inverse variance weighted | 2.120524|    5| 0.8322295|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0017915| 0.0058756| 0.7756458|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.44e-05|              0|TRUE                     |    0.5911345|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/EDTA_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/EDTA_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/EDTA_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/EDTA_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
