

# Two sample MR report

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## Hepatocyte growth factor levels against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   14| -0.0175009| 0.0364535| 0.6397962|
|Weighted median           |   14|  0.0279864| 0.0187343| 0.1352115|
|Inverse variance weighted |   14|  0.0403761| 0.0154004| 0.0087479|
|Simple mode               |   14|  0.0201316| 0.0292729| 0.5037142|
|Weighted mode             |   14|  0.0247210| 0.0218240| 0.2777817|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 11.83246|   12| 0.4592269|
|Inverse variance weighted | 14.82111|   13| 0.3186530|

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### Test for directional horizontal pleiotropy


| egger_intercept|       se|      pval|
|---------------:|--------:|---------:|
|       0.0060352| 0.003491| 0.1094666|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        8.24e-05|          2e-07|TRUE                     |    0.3863337|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Hepatocyte_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Hepatocyte_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Hepatocyte_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Hepatocyte_growth_factor_levels_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
