

# Two sample MR report

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## Interleukin-10 levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |   16| -0.1448886| 0.0994117| 0.1670536|
|Weighted median           |   16| -0.0479756| 0.0595446| 0.4204108|
|Inverse variance weighted |   16| -0.1053981| 0.0440642| 0.0167603|
|Simple mode               |   16| -0.2554413| 0.1179577| 0.0468728|
|Weighted mode             |   16| -0.0009527| 0.0890860| 0.9916080|

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### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 10.31484|   14| 0.7388221|
|Inverse variance weighted | 10.51122|   15| 0.7864114|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|     pval|
|---------------:|---------:|--------:|
|       0.0040911| 0.0092318| 0.664426|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        0.000112|              0|TRUE                     |    0.2310807|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin10_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin10_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Interleukin10_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin10_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk8-1.png)
