

# Two sample MR report

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## Histidine against Amyotrophic lateral sclerosis || id:ieu-a-1085

Date: **03 January, 2026**

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### Results from two sample MR:


|method                    | nsnp|          b|        se|      pval|
|:-------------------------|----:|----------:|---------:|---------:|
|MR Egger                  |    4|  0.2260377| 0.1337259| 0.2330355|
|Weighted median           |    4| -0.0922457| 0.0295968| 0.0018286|
|Inverse variance weighted |    4| -0.0671624| 0.0285231| 0.0185394|
|Simple mode               |    4| -0.1014960| 0.0436143| 0.1024160|
|Weighted mode             |    4| -0.1011682| 0.0468956| 0.1198795|

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### Heterogeneity tests


|method                    |         Q| Q_df|    Q_pval|
|:-------------------------|---------:|----:|---------:|
|MR Egger                  | 0.1408367|    2| 0.9320038|
|Inverse variance weighted | 5.0807947|    3| 0.1659757|

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### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|      -0.0260874| 0.0117373| 0.1563094|

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### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        3.36e-05|          1e-07|TRUE                     |    0.5333698|

Note - R^2 values are approximate

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### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Histidine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk5-1.png)

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### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Histidine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk6-1.png)

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### Funnel plot

![plot of chunk chunk7](figure/Histidine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk7-1.png)

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### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Histidine_against_Amyotrophic_lateral_sclerosis__idieua1085chunk8-1.png)
