

# Two sample MR report

---

## Interleukin-13 levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164

Date: **03 January, 2026**

---

### Results from two sample MR:


|method                    | nsnp|         b|        se|      pval|
|:-------------------------|----:|---------:|---------:|---------:|
|MR Egger                  |   10| 0.0063972| 0.1523335| 0.9675320|
|Weighted median           |   10| 0.1347364| 0.0766551| 0.0787989|
|Inverse variance weighted |   10| 0.1270389| 0.0567034| 0.0250642|
|Simple mode               |   10| 0.1490010| 0.1078033| 0.2002584|
|Weighted mode             |   10| 0.1500785| 0.1031166| 0.1795277|

---

### Heterogeneity tests


|method                    |        Q| Q_df|    Q_pval|
|:-------------------------|--------:|----:|---------:|
|MR Egger                  | 1.695213|    8| 0.9889734|
|Inverse variance weighted | 2.423289|    9| 0.9828758|

--- 

### Test for directional horizontal pleiotropy


| egger_intercept|        se|      pval|
|---------------:|---------:|---------:|
|       0.0109535| 0.0128371| 0.4183212|

--- 

### Test that the exposure is upstream of the outcome


| snp_r2.exposure| snp_r2.outcome|correct_causal_direction | steiger_pval|
|---------------:|--------------:|:------------------------|------------:|
|        4.19e-05|              0|TRUE                     |    0.5047566|

Note - R^2 values are approximate

---

### Forest plot of single SNP MR

![plot of chunk chunk5](figure/Interleukin13_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk5-1.png)

---

### Comparison of results using different MR methods

![plot of chunk chunk6](figure/Interleukin13_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk6-1.png)

---

### Funnel plot

![plot of chunk chunk7](figure/Interleukin13_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk7-1.png)

---

### Leave-one-out sensitivity analysis

![plot of chunk chunk8](figure/Interleukin13_levels_against_Amyotrophic_lateral_sclerosis__idebiaGCST90027164chunk8-1.png)
