Two sample MR report
Interleukin-2 || id:prot-a-1512 against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.145 | 0.193 | 0.590 |
| Weighted median | 3 | -0.146 | 0.066 | 0.028 |
| Inverse variance weighted | 3 | -0.114 | 0.058 | 0.048 |
| Simple mode | 3 | -0.169 | 0.087 | 0.193 |
| Weighted mode | 3 | -0.169 | 0.098 | 0.227 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.26 | 1 | 0.261 |
| Inverse variance weighted | 1.30 | 2 | 0.522 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.007 | 0.044 | 0.894 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.387 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
