Two sample MR report
Interleukin-2 || id:prot-a-1512 against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.005 | 0.046 | 0.926 |
| Weighted median | 4 | -0.033 | 0.014 | 0.019 |
| Inverse variance weighted | 4 | -0.032 | 0.012 | 0.006 |
| Simple mode | 4 | -0.034 | 0.020 | 0.192 |
| Weighted mode | 4 | -0.036 | 0.017 | 0.130 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.23 | 2 | 0.541 |
| Inverse variance weighted | 1.90 | 3 | 0.593 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.008 | 0.009 | 0.498 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.001 | 0 | TRUE | 0.198 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
