Two sample MR report
Interleukin-2 receptor subunit beta || id:prot-a-1519 against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.579 | 0.956 | 0.653 |
| Weighted median | 3 | -0.136 | 0.068 | 0.044 |
| Inverse variance weighted | 3 | -0.123 | 0.058 | 0.033 |
| Simple mode | 3 | -0.191 | 0.095 | 0.183 |
| Weighted mode | 3 | -0.192 | 0.101 | 0.197 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.44 | 1 | 0.229 |
| Inverse variance weighted | 2.23 | 2 | 0.329 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.097 | 0.132 | 0.596 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0 | 0 | TRUE | 0.369 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
