Two sample MR report
RBC distribution width (RDW) against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.2712454 | 0.3105696 | 0.4745526 |
| Weighted median | 4 | -0.2459515 | 0.1026414 | 0.0165650 |
| Inverse variance weighted | 4 | -0.2144419 | 0.1038034 | 0.0388429 |
| Simple mode | 4 | -0.3801305 | 0.1611891 | 0.0995542 |
| Weighted mode | 4 | -0.2346017 | 0.1171841 | 0.1390573 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.047139 | 2 | 0.1321828 |
| Inverse variance weighted | 4.128140 | 3 | 0.2479556 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.001424 | 0.0071173 | 0.8599226 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2e-07 | 0 | TRUE | 0.9534698 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
