Two sample MR report
IL_16 against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0103262 | 0.0125568 | 0.4973167 |
| Weighted median | 4 | 0.0133431 | 0.0080513 | 0.0974682 |
| Inverse variance weighted | 4 | 0.0150496 | 0.0073943 | 0.0418215 |
| Simple mode | 4 | 0.0145156 | 0.0141326 | 0.3799449 |
| Weighted mode | 4 | 0.0120547 | 0.0086688 | 0.2585515 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.373056 | 2 | 0.3052794 |
| Inverse variance weighted | 2.658323 | 3 | 0.4473565 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0016847 | 0.0034359 | 0.6724166 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0016331 | 0 | TRUE | 0.0224742 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
