Two sample MR report
Amyotrophic lateral sclerosis || id:ieu-a-1085 against FGF_BASIC
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 30 | -0.7403558 | 0.3878249 | 0.0665605 |
| Weighted median | 30 | -0.3775911 | 0.2340401 | 0.1066662 |
| Inverse variance weighted | 30 | -0.3827948 | 0.1633227 | 0.0190887 |
| Simple mode | 30 | -0.8451983 | 0.4147742 | 0.0507915 |
| Weighted mode | 30 | -0.5070952 | 0.3538028 | 0.1624744 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 29.20744 | 28 | 0.4020631 |
| Inverse variance weighted | 30.28500 | 29 | 0.3998786 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0096263 | 0.0094712 | 0.3181547 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0238754 | 0.0047341 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
