Two sample MR report
Amyotrophic lateral sclerosis || id:ieu-a-1085 against SCGF_B
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 30 | -0.9702553 | 0.5524041 | 0.0899497 |
| Weighted median | 30 | -0.5911613 | 0.3228989 | 0.0671313 |
| Inverse variance weighted | 30 | -0.5206371 | 0.2295975 | 0.0233531 |
| Simple mode | 30 | -0.6345948 | 0.5950513 | 0.2950169 |
| Weighted mode | 30 | -0.6860091 | 0.4646188 | 0.1505874 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 26.22406 | 28 | 0.5607297 |
| Inverse variance weighted | 27.02489 | 29 | 0.5703622 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0119781 | 0.0133851 | 0.3784754 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0238754 | 0.0086519 | TRUE | 0.0002865 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
