Two sample MR report
beta-nerve growth factor levels against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.0301664 | 0.0500884 | 0.5566288 |
| Weighted median | 16 | 0.0151977 | 0.0225353 | 0.5000610 |
| Inverse variance weighted | 16 | 0.0317428 | 0.0159325 | 0.0463347 |
| Simple mode | 16 | 0.0909488 | 0.0493649 | 0.0852744 |
| Weighted mode | 16 | 0.0916721 | 0.0539829 | 0.1101175 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.82570 | 14 | 0.3901723 |
| Inverse variance weighted | 16.61672 | 15 | 0.3422879 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0052562 | 0.0040417 | 0.2144346 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.27e-05 | 0 | TRUE | 0.4801253 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
