Two sample MR report
Fms-related tyrosine kinase 3 ligand levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | -0.1763363 | 0.1034574 | 0.1037873 |
| Weighted median | 22 | -0.0701412 | 0.0529152 | 0.1849922 |
| Inverse variance weighted | 22 | -0.0786842 | 0.0374143 | 0.0354613 |
| Simple mode | 22 | -0.0280778 | 0.0894268 | 0.7566373 |
| Weighted mode | 22 | -0.0449914 | 0.0753018 | 0.5565751 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 17.97907 | 20 | 0.5887874 |
| Inverse variance weighted | 19.00404 | 21 | 0.5848811 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.00882 | 0.0087119 | 0.3234348 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001104 | 0 | TRUE | 0.2331873 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
