Two sample MR report
Hepatocyte growth factor levels against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | -0.0175009 | 0.0364535 | 0.6397962 |
| Weighted median | 14 | 0.0279864 | 0.0187343 | 0.1352115 |
| Inverse variance weighted | 14 | 0.0403761 | 0.0154004 | 0.0087479 |
| Simple mode | 14 | 0.0201316 | 0.0292729 | 0.5037142 |
| Weighted mode | 14 | 0.0247210 | 0.0218240 | 0.2777817 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.83246 | 12 | 0.4592269 |
| Inverse variance weighted | 14.82111 | 13 | 0.3186530 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0060352 | 0.003491 | 0.1094666 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.24e-05 | 2e-07 | TRUE | 0.3863337 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
