Two sample MR report
Interleukin-10 levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.1448886 | 0.0994117 | 0.1670536 |
| Weighted median | 16 | -0.0479756 | 0.0595446 | 0.4204108 |
| Inverse variance weighted | 16 | -0.1053981 | 0.0440642 | 0.0167603 |
| Simple mode | 16 | -0.2554413 | 0.1179577 | 0.0468728 |
| Weighted mode | 16 | -0.0009527 | 0.0890860 | 0.9916080 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 10.31484 | 14 | 0.7388221 |
| Inverse variance weighted | 10.51122 | 15 | 0.7864114 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0040911 | 0.0092318 | 0.664426 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000112 | 0 | TRUE | 0.2310807 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
