Two sample MR report
Interleukin-10 receptor subunit alpha levels against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0352468 | 0.0677554 | 0.6303847 |
| Weighted median | 6 | 0.0615171 | 0.0272820 | 0.0241419 |
| Inverse variance weighted | 6 | 0.0597910 | 0.0218217 | 0.0061444 |
| Simple mode | 6 | 0.0705213 | 0.0440500 | 0.1702892 |
| Weighted mode | 6 | 0.0736503 | 0.0424173 | 0.1430200 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.954722 | 4 | 0.5654310 |
| Inverse variance weighted | 3.101131 | 5 | 0.6843978 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0021854 | 0.0057114 | 0.7214535 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.7e-05 | 0 | TRUE | 0.639228 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
