Two sample MR report
Interleukin-13 levels against Amyotrophic lateral sclerosis || id:ebi-a-GCST90027164
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0063972 | 0.1523335 | 0.9675320 |
| Weighted median | 10 | 0.1347364 | 0.0766551 | 0.0787989 |
| Inverse variance weighted | 10 | 0.1270389 | 0.0567034 | 0.0250642 |
| Simple mode | 10 | 0.1490010 | 0.1078033 | 0.2002584 |
| Weighted mode | 10 | 0.1500785 | 0.1031166 | 0.1795277 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.695213 | 8 | 0.9889734 |
| Inverse variance weighted | 2.423289 | 9 | 0.9828758 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0109535 | 0.0128371 | 0.4183212 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.19e-05 | 0 | TRUE | 0.5047566 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
