Two sample MR report
Gamma-glutamyltyrosine against Amyotrophic lateral sclerosis || id:ieu-a-1085
Date: 03 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.1498077 | 1.1996685 | 0.9085209 |
| Weighted median | 5 | 0.3625812 | 0.1923230 | 0.0593931 |
| Inverse variance weighted | 5 | 0.3630263 | 0.1576813 | 0.0213195 |
| Simple mode | 5 | 0.4010226 | 0.2446665 | 0.1765441 |
| Weighted mode | 5 | 0.3890118 | 0.2330873 | 0.1704506 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4429131 | 3 | 0.9312417 |
| Inverse variance weighted | 0.4750568 | 4 | 0.9758833 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0022925 | 0.0127867 | 0.8691379 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001032 | 0 | TRUE | 0.4394753 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
